UTERINE FACTOR INFERTILITY: A MAJOR ISSUE OF THE PRESENT AGE
DOI:
https://doi.org/10.71146/kjmr771Keywords:
Uterine Factor Infertility, Absolute Uterine Factor Infertility, Uterus Transplantation, Hysterectomy, Prevalence, Mayer-Rokitansky-Küster-Hauser Syndrome, Reproductive MedicineAbstract
Uterine Factor Infertility (UFI) represents a definitive and challenging subtype of female infertility, characterized by the uterus itself being the principal barrier to gestation. It encompasses Absolute UFI (AUFI), involving anatomical absence, and Non-Absolute UFI (NAUFI), involving a nonfunctional uterus. This systematic review synthesizes current evidence on the epidemiology, etiologies, and treatment landscape of UFI. Despite its clinical significance, reliable population-based and age-stratified prevalence data, particularly for women under 40, remain scarce. A key finding is the variable prevalence of hysterectomy—a major cause of AUFI—ranging from 1.70% to 10.0% in international studies. Congenital anomalies, intrauterine pathologies, and iatrogenic damage constitute other primary causes. For women with AUFI, traditional paths to biological parenthood are limited to adoption or surrogacy. Uterus transplantation (UTx) has emerged as a pioneering, albeit experimental, treatment offering the potential for gestation, with over 50 live births reported globally. However, significant surgical, immunosuppressive, and ethical challenges persist. This review underscores the urgent need for robust epidemiological studies to guide resource allocation and highlights UTx as a dynamic frontier in restoring reproductive potential for this patient population.
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Copyright (c) 2025 Sana Bahadar, Amir Nawaz, Hilal Ahmad Malik (Author)
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