STUDY OF THE CORRELATION BETWEEN HELICOBACTER PYLORI INFECTION AND URIC ACID

Abstract

This study examines the intricate relationship between Helicobacter pylori (H. pylori) infection and elevated uric acid levels, investigating their combined impact on metabolic pathways and the development of chronic diseases. H. pylori, notable for its colonization of the stomach lining, is closely associated with gastritis and peptic ulcers due to its production of urease, which alters the gastric environment, potentially leading to inflammation and ulcers. Various demographic factors, including age, race, ethnicity, and socioeconomic status, contribute to the rates of H. pylori infection across diverse populations. On the other hand, uric acid, a byproduct of purine metabolism, plays a critical role in numerous physiological processes. Dysregulation of uric acid levels, whether from impaired renal function or increased production, has been linked to conditions such as gout, kidney stones, and metabolic syndrome. This investigation delves into the mechanisms through which H. pylori infection and chronic inflammation influence uric acid metabolism. Chronic inflammation may lead to elevated purine production and hinder the excretion of uric acid by the kidneys. Furthermore, immune cell activity and tissue breakdown contribute to increased availability of uric acid precursors. Elevated uric acid levels have been associated with an increased risk of cardiovascular diseases, metabolic syndrome, and kidney disease, thereby posing significant health risks. Additionally, this study explores the potential link between elevated uric acid and insulin resistance, a known precursor to type 2 diabetes and cardiovascular diseases. Insights into the disruption of insulin signaling pathways and mitochondrial function shed light on the intricate interplay between H. pylori infection, uric acid levels, and metabolic dysregulation. Our study comprised of 249 patients out of which 140 were tested positive for H. Pylori. Among those positive tested patients, 46 were found to have elevated uric acid levels in their blood. This showed the clear correlation of the two and that H. pylori is capable of increasing uric acid levels in the body.