ANTI COMPULSIVE ACTIVITY OF ETHANOL EXTRACT OF LEAVES OF MALVA PARVIFLORA IN MICE

Abstract

Background: Obsessive-compulsive disorder is a widespread mental health condition that affects many individuals globally. Malva parviflora L. is a magnificent gift from nature to humanity. This plant has demonstrated its pharmacological promise in treating a variety of illnesses. Leaves are used to treat swelling and wounds. Bruises and broken limbs are treated with a lotion derived from the leaves.  Plants have long been recognized as a significant natural antioxidant source. Among these plants is Malva parviflora. Flavonoid and phenolic compounds are present in the plant. This is the first ever study which assesses the anti-compulsive activity of Malva parviflora L.

Material and method:  Each mouse was housed in a standard 22 x 32 x 13.5 cm cage with 24 glass marbles (1.5 cm in diameter) and a 5 cm layer of sawdust. After administering the test substance, the vehicle, and the conventional medication, fluoxetine, the animals were left in their cages for the following half hour. For each mouse, the quantity of marbles buried in the sawdust throughout a 30-minute period was noted.

Result: In the present study, ethanol extract of the leaves of Malva parviflora (250 and 500 mg/kg, p.o.) has shown a significant anti-compulsive effect in mice. This is the first report demonstrating the ability of Malva parviflora leaves to control obsessive behavior. The results are comparable to the standard drug, fluoxetine.

Conclusion: According to our current research, Malva parviflora's active chemical components have a strong anti-compulsive impact. To confirm the mechanism of action behind the results seen in our study, more research is necessary.