ANTIDEPRESSANT-LIKE ACTIVITY OF LENTINULA EDODES MUSHROOM IN MICE
DOI:
https://doi.org/10.71146/kjmr550Keywords:
Lentinula edodes, depression, tail suspension test, forced swim test, home-cage test.Abstract
Background: Depression is considered as the most common health issue, because of its high level of occurrence worldwide. It is considered as one of the major cause of mental disability. Mushrooms have emerged as promising candidates due to their neuroactive compounds.
Objective: This study was conducted to evaluate the antidepressant-like effects of Lentinula edodes (shiitake mushroom) extract in mice using two doses: 250 mg/kg and 500 mg/kg per oral.
Material and Method: Behavioral assessments were conducted using the Forced Swimming Test (FST) and Tail Suspension Test (TST) to measure depressive-like behaviors, while the Home Cage Test was used to evaluate locomotor activity and rule out nonspecific motor stimulation.
Result: The dose 500 mg/kg significantly reduced immobility time in both FST and TST compared to the control group, indicating a strong antidepressant-like effect. No significant changes in locomotor activity were observed in the Home Cage Test, suggesting that the observed behavioral effects were not due to increased general activity.
Conclusion: These findings suggest that Lentinula edodes possesses dose-dependent antidepressant-like properties and may serve as a potential natural therapeutic candidate for the treatment of depression.
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Copyright (c) 2025 Madeha, Muhammad Aslam, Shahnaz Niaz, Rabia Fatima, Hammad Ahmed (Author)
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